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Advocates pushed Gov. Cuomo to allow the city to open supervised sites for drug users to inject heroin Wednesday — as a state pol moved to block the centers from opening.

The battle shifted to the state level after Mayor de Blasio endorsed a plan to open four privately-run supervised injection sites in the city.

The sites — meant to cut down on overdose deaths — do not exist anywhere in the United States and violate federal law, though they have opened in cities around the world.

De Blasio says he'll go forward if he gets the OK from Cuomo's health commissioner, Dr. Howard Zucker.

Protesters at Cuomo's Manhattan office Wednesday urged him to sign off, holding signs saying, "Gov. Cuomo, while you wait New Yorkers die of preventable overdoses."

"It is not just sound science. It is not just about good public health. This is about saving the lives of people who we love," said Charles King, president of Housing Works.

"Commissioner Zucker and Gov. Cuomo now have no excuse."

But Assemblywoman Nicole Malliotakis (R-Staten Island) wrote to Zucker asking him to block the plan, and to Attorney General Jeff Sessions urging him to crack down.

She also introduced a bill that would pull state funding from any group that runs a supervised injection facility.

"Aside from violating federal law and the ability of police officers to enforce it, authorizing these facilities will also redefine the way we combat drug use and addiction on the most fundamental level," she wrote.

"Rather than educating youth about the dangers of opioids, focusing on getting hardened drug dealers poisoning our children off the streets, and offering addicts effective treatment, we will instead signal to users that addiction is a manageable condition and you can partake in illegal opioid use nearly risk-free."

A federal law, known as the crack house statute, makes it illegal to operate a location that facilitates drug use.

The Justice Department has not said how it would respond to the opening of injection sites, which are also being considered in a handful of other U.S. cities, but has pointed to a statement by the U.S. Attorney in Vermont warning against them.

De Blasio's plan calls for four sites — two in Manhattan, one in Brooklyn and one in the Bronx.

Cuomo's office did not immediately respond to a request for comment Wednesday.

Cuomo preciously said the sites were a "complicated matter" which he would review.