Moderna chief predicts current vaccines will struggle with omicron variant

almost 4 years in The Irish Times

The plethora of mutations in the omicron variant are likely to help it evade protection provided by existing vaccines, making it necessary to develop new immunisations, according to the CEO of Moderna.
Stephane Bancel told the Financial Times it may take months for pharmaceutical companies to develop and deploy updated immunisations that they can deliver in large numbers.
“There is no world, I think, where [the effectiveness] is the same level . . . we had with (the) Dellta (variant),” Bancel said in the interview.
The current vaccines from companies including Moderna, Pfizer Inc. and BioNTech SE, AstraZeneca Plc and Johnson and Johnson are all able to help reduce the risk of severe infection and death from the previous strains of the virus, though they work less well against the more transmissible delta variant.
Research is still underway to determine if omicron causes the same level of illness as older versions of the virus, if it can evade protection from vaccines and previous infections, and if it will be able to outcompete the existing strains as the pathogen continues to circulate throughout the world.
Pfizer Chief Executive Officer Albert Bourla said his company will be ready with a vaccine targeting omicron in 100 days, should it be necessary.
Meanwhile, Japan has confirmed its first case of the omicron coronavirus variant after a test on a visitor who recently arrived from Namibia in southern Africa.
Isolated
Chief cabinet secretary Hirokazu Matsuno said the man in his 30s tested positive on arrival at an airport on Sunday and was isolated and is being treated in hospital. A genome analysis confirmed that he was infected with the new variant, which was first identified in South Africa.
Japan announced on Monday that it will ban all foreign visitors from Tuesday as an emergency precaution against the variant. The World Health Organisation warned on Monday that the global risk from the Omicron variant is “very high” based on the early evidence, saying it could lead to surges with “severe consequences”.
In Australia, the New South Wales government has introduced new testing measures and increased fines for returned travellers who breach new Omicron isolation rules, hours after Scott Morrison urged premiers to “not get spooked” by the new variant.
On Tuesday evening, as NSW Health confirmed the Omicron strain had been detected in a fifth returned traveller in the state, premier Dominic Perrottet announced fines for breaching the 72 hour home isolation requirement, introduced in response to the variant, would rise to AUS$5,000, up from $1,000.
Additionally, all returned travellers - who are already required to get a negative PCR test in order to finish their three day home quarantine - will now also be required to get an additional PCR test six days after arriving in the state and three days after finishing their isolation.
US President Joe Biden has cautioned Americans against panicking, urging them to instead get vaccinated or have an extra shot.
“This variant is a cause for concern. Not a cause for panic,” Biden said in remarks at the White House after a private briefing from his health advisers. He said the administration doesn’t yet believe new formulations of coronavirus vaccines will be necessary but that it is already working with Pfizer Inc. and Moderna Inc. on contingency plans.Anthony S. Fauci, the White House’s chief medical adviser for Covid-19, said Monday that his South African colleagues told him “at least some of the rapid antigen tests” could detect the variant first discovered by South African scientists last week.
The Centers for Disease Control and Prevention expanded its recommendation for boosters to all adults as cases top 262 million and deaths pass 5.2 million. -Reuters

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