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Prime Minister Scott Morrison has urged Melburnians to "tough it out" as the city prepares for a six week lockdown starting from midnight.

Premier Daniel Andrews has confirmed 134 new coronavirus cases in Victoria in the past 24 hours, 75 of which are from public housing towers across Melbourne.

Under the state's new lockdown measures - set to come into full force at midnight tonight - the state will remain closed for up to six weeks before the government considers easing restrictions.

Speaking to reporters ahead of the lockdown, Mr Morrison said the nation is completely behind Melbourne.

"We will keep doing our job and I know Australians will keep doing theirs," he said.

"And right now, that job is if you’re a Melburnian, is to tough it out and it will be tough, but know the rest of the country is with you.

"The rest of the country knows that the sacrifice that you’re going through right now is not just for you and your own family, but it’s for the broader Australian community. And I want to thank Melburnians."

The prime minister said at this stage, the government does not believe lockdowns should be implemented nationwide.